J Neurol Neurosurg Psychiatry 64(4):435–443. Zeman AZ, Boniface SJ, Hodges JR (1998) Transient epileptic amnesia: a description of the clinical and neuropsychological features in 10 cases and a review of the literature. More broadly, our results suggest an etiological heterogeneity in TEA. It argues for TEA being the inaugurating feature in some cases of AD. This study shows a good diagnostic value of CSF sampling in a specific population of TEA with characteristics suggestive of incipient degenerative diseases (i.e., red flags). CSF analyses revealed amyloid and/or tau changes in 27 patients (38%), including an Alzheimer’s disease (AD) profile in 17 (24%). At follow-up, the CSF-TEA group had significantly ( p < 0.01) lower MMSE scores (27.8 vs. 42.6%), and more atrophic hippocampal changes. 28.9), a more frequent amnestic mild cognitive impairment profile (69% vs. 9.4%), a lower baseline MMSE score (27 vs. 10.7%), a more blunted sense of smell (34.3% vs. ResultsĪt baseline, the CSF-TEA group had significantly ( p < 0.01) more frequent mild parkinsonism (42.9% vs. CSF samples were examined for amyloid β-42 peptide as well as phospho-tau and total-tau levels. Both were compared for demographics medical history baseline neurological, cognitive, and behavioral features baseline mesial temporal lobe atrophy and cognitive follow-up at a median of 13 months. In this retrospective study, 127 TEA patients with unremarkable imaging findings were divided into 2 groups, namely, CSF ( n = 71) and no-CSF ( n = 56). We, therefore, examined the yield of CSF amyloid and tau biomarkers in TEA. doi:10.Transient epileptic amnesia (TEA) is a late-onset epilepsy syndrome encompassing transient iterative amnesias and interictal cognitive impairment, two features that overlap with incipient neurodegenerative dementias. Acute-Onset Amnesia: Transient Global Amnesia and Other Causes. What Does Transient Global Amnesia Really Mean? Review of the Literature and Thorough Study of 142 Cases. Quinette P, Guillery-Girard B, Dayan J et al. Transient Global Amnesia: Diffusion-Weighted Imaging Lesions and Cerebrovascular Disease. Optimal Diffusion-Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia. High-Resolution Diffusion-Weighted Imaging Increases Lesion Detectability in Patients with Transient Global Amnesia. Post-traumatic amnesia, has a history of trauma 6 Psychogenic amnesia, more-so affects semantic memory compared to episodic memory, while TGA is the opposite 6ĭrug-related amnesia, typically has features of encephalopathy 6 Transient epileptic amnesia, typically presents upon waking while TGA does not 6 hippocampal ischemic), typically exists with other neurological deficits 6 The condition rarely recurs in ~5% of patients 5,6. These changes generally appear after symptom resolution, and the highest rate of detection is approximately 2 days after symptom onset 6. These lesions can be bilateral and even multifocal 2-4. Prospective and retrospective studies based on a small number of transient global amnesia patients can detect small punctate regions of abnormally restricted diffusion on DWI/ADC sequences in the CA1 area of the hippocampus (lateral edge of the hippocampal gyrus abutting the temporal horn). Radiographic featuresĬT brain and conventional sequences of MRI brain may show no abnormalities, especially while the patient is symptomatic.

epileptic phenomena, stroke, focal ischemia) have been proposed with no consensus on the exact mechanism 1,6. Most cases show complete resolution of symptoms within a few hours from onset of symptoms 6. Episodic memories are more-so affected than semantic memories 6. AssociationsĪnterograde and partial retrograde amnesia lasting less than 24 hours without any other neurological or congestive symptoms 6. Transient global amnesia is most common in the 50-70 year age range ref.